<p>This entry contains shikimate and quinate dehydrogenases, as well as glutamyl-tRNA reductases.</p><p>Shikimate 5-dehydrogenase (<db_xref db="EC" dbkey="1.1.1.25"/>) catalyses the conversion of shikimate to 5-dehydroshikimate [<cite idref="PUB00028042"/>, <cite idref="PUB00028043"/>]. This reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids [<cite idref="PUB00014334"/>]. Quinate 5-dehydrogenase catalyses the conversion of quinate to 5-dehydroquinate. This reaction is part of the quinate pathway where quinic acid is exploited as a source of carbon in prokaryotes and microbial eukaryotes. Both the shikimate and quinate pathways share two common pathway metabolites, 3-dehydroquinate and dehydroshikimate.</p><p>Glutamyl-tRNA reductase (<db_xref db="EC" dbkey="1.2.1.70"/>) catalyzes the first step of tetrapyrrole biosynthesis in plants, archaea and most bacteria. The dimeric enzyme has an unusual V-shaped architecture where each monomer consists of three domains linked by a long 'spinal' alpha-helix. The central catalytic domain specifically recognises the glutamate moiety of the substrate [<cite idref="PUB00035783"/>]. </p> Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase